The stability of oncologic MRI radiomic features and the potential role of deep learning: a review

The use of MRI radiomic models for the diagnosis, prognosis and treatment response prediction of tumors has been increasingly reported in literature. However, its widespread adoption in clinics is hampered by issues related to features stability. In the MRI radiomic workflow, the main factors that affect radiomic features computation can be found in the image acquisition and reconstruction phase, in the image pre-processing steps, and in the segmentation of the region of interest on which radiomic indices are extracted. Deep Neural Networks (DNNs), having shown their potentiality in the medical image processing and analysis field, can be seen as an attractive strategy to partially overcome the issues related to radiomic stability and mitigate their impact. In fact, DNN approaches can be prospectively integrated in the MRI radiomic workflow to improve image quality, obtain accurate and reproducible segmentations and generate standardized images. In this review, DNN methods that can be included in the image processing steps of the radiomic workflow are described and discussed, in the light of a detailed analysis of the literature in the context of MRI radiomic reliability.