沙丁胺醇
透皮
生物利用度
离体
渗透
药代动力学
粒径
药理学
色谱法
体内
超声
Zeta电位
材料科学
支气管扩张剂
化学
医学
哮喘
纳米颗粒
体外
纳米技术
生物化学
内科学
生物技术
物理化学
生物
膜
作者
Huifang Zhang,Yanjie Cui,Xiaochun Zhang,Xunling Yuan,Di Xu,Lei Zhang
标识
DOI:10.1080/02652048.2022.2060362
摘要
In the current study, efforts are being made to formulate transdermal salbutamol-cubosomal gel to manage paediatric asthma.Salbutamol-loaded cubosomal gels were prepared by melt emulsification and sonication. The cubosomal gels were characterised by morphology, particle size, zeta potential, entrapment efficacy, assay, viscosity, and texture profiles. Ex vivo permeation and pharmacokinetic studies were performed using rats.The mean cubosomal particle size (208-361 ± 12.5-32.5 nm), PDI (0.06-0.11 ± 0.01-0.02), viscosity (8527-9019 cp), and entrapment efficacy (76.3-91.0% w/w) increase with the level of monoolein. The ex vivo permeation study showed a biphasic release pattern, with salbutamol cleared from control gel within 8 h, while cubosomal gels showed sustained release up to 72 h. The pharmacokinetic profiles in the rat model showed 8.62-fold higher bioavailability with cubosomal gel.The study demonstrated the potential of cubosomal nanoparticle-laden gel to sustain the release of salbutamol to treat paediatric asthma.
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