烟酰胺
抗菌肽
抗菌剂
先天免疫系统
体内
皮肤感染
免疫系统
黑色素
药剂师
药理学
生物
免疫学
医学
细菌
微生物学
金黄色葡萄球菌
生物化学
生物技术
烟酰胺
酶
遗传学
作者
Mruthyunjaya Swamy Mathapathi,Prathyusha Mallemalla,Shilpa Vora,Vidula Iyer,Jyoti Tiwari,Amit Chakrabortty,A.K. Majumdar
摘要
Antimicrobial peptides (AMPs) form a part of the skin's innate immune system. Their primary activity is to provide antimicrobial benefits and hence protect from infections. AMPs that are present on human skin include psoriasin (S100A7), RNase 7, lysozyme, LL-37 and defensins. Niacinamide is a well-known cosmetic ingredient that has been used traditionally for multiple skin benefits. Recent data indicate that niacinamide treatment can boost AMPs in human gut epithelial cells and in neutrophils. Treatment with niacinamide in mice also provided protection from skin infections by enhancing AMPs. In this article, we find that treatment with niacinamide formulation provides long-lasting protection against bacteria, potentially through the activation of an AMP response.
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