MP90-20 SHOULD WE SUSPEND MEDICAL EXPULSIVE THERAPY: A PROSPECTIVE RANDOMIZED TRIAL

You have accessJournal of UrologyStone Disease: Medical & Dietary Therapy1 Apr 2017MP90-20 SHOULD WE SUSPEND MEDICAL EXPULSIVE THERAPY: A PROSPECTIVE RANDOMIZED TRIAL Prarthan Joshi, Prasad Mylarappa, Puvvada Sandeep, Ramesh Desigowda, Arvind Nayak, and Kuldeep Aggarwal Prarthan JoshiPrarthan Joshi More articles by this author , Prasad MylarappaPrasad Mylarappa More articles by this author , Puvvada SandeepPuvvada Sandeep More articles by this author , Ramesh DesigowdaRamesh Desigowda More articles by this author , Arvind NayakArvind Nayak More articles by this author , and Kuldeep AggarwalKuldeep Aggarwal More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.2839AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES In recent years, medical expulsive therapy has been questioned in the management of distal ureteric stones. Therefore, we conducted a prospective randomized study to evaluate the possible role of tadalafil individually and in comparison with proven tamsulosin as well as a placebo therapy in distal ureteric stone expulsion. METHODS Between January 2015 and March 2016, 327 patients who presented with distal ureteric stones of size 5–10 mm were randomly divided into three groups: tadalafil (Group A), tamsulosin (Group B), and placebo (Group C). Therapy was given for a maximum of 4 weeks. Stone expulsion rate, time to stone expulsion, analgesic use, number of hospital visits for pain, follow-up, endoscopic treatment and adverse effects of drugs were noted. RESULTS A statistically significant expulsion rate of 86.0% in Group A compared with 66.0% in Group B and 38.0% in Group C was observed. Also a shorter stone expulsion time in Group A (13.5 ± 2.5) in comparison to Group B (16.4 ± 3.5) and Group C (24.8 ± 4.5) was observed. Statistically significant differences were noted in renal colic episodes and analgesic requirement in Group A in comparison to Group B and Group C. No serious adverse effects were noted. CONCLUSIONS Tadalafil is safe, efficacious, and well tolerated as medical expulsive therapy for distal ureteric stones. This study showed that tadalafil increases ureteric stone expulsion quite significantly along with better control of pain and significantly lower analgesic requirement. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e1218 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Prarthan Joshi More articles by this author Prasad Mylarappa More articles by this author Puvvada Sandeep More articles by this author Ramesh Desigowda More articles by this author Arvind Nayak More articles by this author Kuldeep Aggarwal More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...