Alkyl Bromides as Mild Hydride Sources in Ni-Catalyzed Hydroamidation of Alkynes with Isocyanates

A catalytic hydroamidation of alkynes with isocyanates using alkyl bromides as hydride sources has been developed. The method turns parasitic β-hydride elimination into a strategic advantage, rapidly affording acrylamides with excellent chemo- and regioselectivity.