花生四烯酸
脂质代谢
脂氧合酶
生物化学
代谢途径
生物
多不饱和脂肪酸
新陈代谢
葡萄糖稳态
内分泌学
内科学
脂肪酸
化学
胰岛素抵抗
酶
糖尿病
医学
作者
Sha Li,Wen Su,Xiaoyan Zhang,Youfei Guan
出处
期刊:Acta physiologica Sinica
日期:2021-08-25
卷期号:73 (4): 657-664
被引量:3
摘要
Arachidonic acid (AA) is an ω-6 polyunsaturated fatty acid, which mainly exists in the cell membrane in the form of phospholipid. Three major enzymatic pathways including the cyclooxygenase (COX), lipoxygenase (LOX) and cytochrome P450 monooxygenase (CYP450) pathways are involved in AA metabolism leading to the generation of a variety of lipid mediators such as prostaglandins, leukotrienes, hydroxyeicosatetraenoic acids (HETEs) and epoxyeicoastrienoic acids (EETs). These bioactive AA metabolites play an important role in the regulation of many physiological processes including the maintenance of liver glucose and lipid homeostasis. As the central metabolic organ, the liver is essential in metabolism of carbohydrates, lipids and proteins, and its dysfunction is associated with the pathogenesis of many metabolic diseases such as type 2 diabetes mellitus, dyslipidemia and nonalcoholic fatty liver disease (NAFLD). This article aims to provide an overview of the enzymatic pathways of AA and discuss the role of AA-derived lipid mediators in the regulation of hepatic glucose and lipid metabolism and their associations with the pathogenesis of major metabolic disorders.
科研通智能强力驱动
Strongly Powered by AbleSci AI