Synergistic effect of cinacalcet and active vitamin D in a dialysis patient with secondary hyperparathyroidism

Abstract While treating a long‐term dialysis patient for secondary hyperparathyroidism (SHPT), indications of a synergistic effect between cinacalcet HCl and active vitamin D were observed. After 2.5 years, high initial cinacalcet doses of 180 mg/day could be significantly reduced to only 30 mg/non‐dialysis day without losing control over the intact parathyroid hormone. Calcium‐phosphorus product improved over time. The combination of cinacalcet and active vitamin D may improve the treatment of SHPT in dialysis patients. Dial. Transplant. © 2010 Wiley Periodicals, Inc.