过氧化氢酶
毒性
谷胱甘肽过氧化物酶
谷胱甘肽
药理学
伏马菌素
生物
化学
毒理
生物化学
抗氧化剂
医学
真菌毒素
酶
生物技术
内科学
作者
Taddesse Yayeh,Ha Ram Jeong,Yoon Soo Park,Sohyeon Moon,Bongjun Sur,Hyun-jung Yoo,Seikwan Oh
出处
期刊:Biomolecules & Therapeutics
[The Korean Society of Applied Pharmacology]
日期:2021-01-01
卷期号:29 (1): 52-57
被引量:3
标识
DOI:10.4062/biomolther.2020.062
摘要
Fumonisin B1 (FB1) structurally resembles sphingolipids and interferes with their metabolism leading to sphingolipid dysregulation. We questioned if FB1 could exacerbate liver or kidney toxicities in glutathione peroxidase 1 (Gpx1) and catalase (Cat) knockout mice. While higher serum levels of thiobarbituric acid reactive substances (TBARS) and sphinganine (Sa) were measured in Gpx1/Cat knockout mice (Gpx1/Cat KO) than wild type mice after 5 days of FB1 treatment, serum levels of alanine aminotransferase (ALT), sphingosine-1 phosphate (So-1-P), and sphinganine-1 phosphate (Sa-1-P) were found to be relatively low. Although Sa was highly elevated in Gpx1/Cat KO mice and wild mice, lower levels of So and Sa were found in both the kidney and liver tissues of Gpx/Cat KO mice than wild type mice after FB1 treatment. Paradoxically, FB1-induced cellular apoptosis and necrosis were hastened under oxidative stress in Gpx1/Cat KO mice.
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