杜氏肌营养不良
磁共振成像
生物标志物
体内
多光谱图像
医学
分子成像
病理
断层摄影术
肌营养不良
骨骼肌
生物医学工程
肌肉组织
放射科
内科学
化学
生物
计算机科学
生物化学
生物技术
计算机视觉
作者
Adrian P. Regensburger,Lina Marie Fonteyne,Jörg Jüngert,Alexandra L. Wagner,Teresa Gerhalter,Armin M. Nagel,Rudolf Heiss,Florian Flenkenthaler,Matthias Qurashi,Markus F. Neurath,Nikolai Klymiuk,Elisabeth Kemter,Thomas Fröhlich,Michael Uder,Joachim Woelfle,Wolfgang Rascher,Regina Trollmann,Eckhard Wolf,Maximilian J. Waldner,Ferdinand Knieling
出处
期刊:Nature Medicine
[Springer Nature]
日期:2019-12-01
卷期号:25 (12): 1905-1915
被引量:126
标识
DOI:10.1038/s41591-019-0669-y
摘要
Biomarkers for monitoring of disease progression and response to therapy are lacking for muscle diseases such as Duchenne muscular dystrophy. Noninvasive in vivo molecular imaging with multispectral optoacoustic tomography (MSOT) uses pulsed laser light to induce acoustic pressure waves, enabling the visualization of endogenous chromophores. Here we describe an application of MSOT, in which illumination in the near- and extended near-infrared ranges from 680-1,100 nm enables the visualization and quantification of collagen content. We first demonstrated the feasibility of this approach to noninvasive quantification of tissue fibrosis in longitudinal studies in a large-animal Duchenne muscular dystrophy model in pigs, and then applied this approach to pediatric patients. MSOT-derived collagen content measurements in skeletal muscle were highly correlated to the functional status of the patients and provided additional information on molecular features as compared to magnetic resonance imaging. This study highlights the potential of MSOT imaging as a noninvasive, age-independent biomarker for the implementation and monitoring of newly developed therapies in muscular diseases.
科研通智能强力驱动
Strongly Powered by AbleSci AI