化学
区域选择性
香豆素
铑
产量(工程)
催化作用
表面改性
脱羧
有机化学
化学计量学
药物化学
迈克尔反应
羧酸
组合化学
物理化学
冶金
材料科学
作者
Shanshan Xun,Litao Jia
出处
期刊:Letters in Organic Chemistry
[Bentham Science]
日期:2021-11-01
卷期号:18 (11): 849-853
标识
DOI:10.2174/1570178617999200818171024
摘要
Rhodium-catalyzed hydrocarbon bond activation of N-heterocycles and decarboxylative Michael addition with coumarin-3-carboxylic acids has been well achieved. Various N-heterocycles substituted 3,4-dihydrocoumarin could be easily provided with excellent chemo- and regioselectivity in good to excellent yields. A class of functional groups on N-heterocycles and coumarin-3-carboxylic acids is compatible with this process. A stoichiometric amount of Zn(OAc)2 is necessary for the high yield of products.
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