Antimicrobial polyketides from an endophytic fungus Arcopilus aureus HJ-7 from Ardisia mamillata Hance

Eleven polyketide derivatives, including two new compounds, xanthoradone D (1) and arisochromophilone (2), were isolated from Arcopilus aureus HJ-7, a Chinese medicinal plant Ardisia mamillata Hance-associated fungus. Their structures were elucidated on the basis of spectroscopic analysis and ECD (Electronic Circular Dichroism) calculations. The antibacterial and antifungal activities of the compounds were evaluated. Compound 1 showed the significant inhibitory activity against Staphylococcus aureus and Xanthomonas axonopodis pv. citri (Hasse) Dye with the MIC (Minimum Inhibitory Concentration) value of 6.25 μg/mL, and 1 also showed strong antifungal activities against Cochliobolus miyabeanus and Ceratocystis paradoxa with the MIC value of 3.125 μg/mL.