The lipogenic enzyme acetoacetyl-CoA synthetase and ketone body utilization for denovo lipid synthesis, a review

脂肪酸合成 生物化学 ATP柠檬酸裂解酶 脂肪组织 化学 酮体 脂质代谢 脂滴 脂肪生成 胆固醇 新陈代谢 柠檬酸合酶
作者
James D. Bergstrom
出处
期刊:Journal of Lipid Research [Elsevier BV]
卷期号:64 (8): 100407-100407 被引量:18
标识
DOI:10.1016/j.jlr.2023.100407
摘要

Acetoacetyl-CoA synthetase (AACS) is the key enzyme in the anabolic utilization of ketone bodies (KBs) for denovo lipid synthesis, a process that bypasses citrate and ATP citrate lyase. This review shows that AACS is a highly regulated, cytosolic and lipogenic enzyme and that many tissues can readily use KBs for denovo lipid synthesis. AACS has a low, micromolar Km for acetoacetate (AcAc) and supply of AcAc should not limit its activity in the fed state. In many tissues AACS appears to be regulated in conjunction with the need for cholesterol, but in adipose tissue it seems tied to fatty acid synthesis. KBs are readily utilized as substrates for lipid synthesis in lipogenic tissues including liver, adipose tissue, lactating mammary gland, skin, intestinal mucosa, adrenals and developing brain. In numerous studied cases, KBs served several-fold better than glucose as substrates for lipid synthesis and when present, KBs suppressed the utilization of glucose for lipid synthesis. Here it is hypothesized that a physiological role for the utilization of KBs for lipid synthesis is a metabolic process of lipid interconversion. Fatty acids are converted to KBs in liver and then the KBs are utilized to synthesize cholesterol and other long-chainfatty acids in liver and non-hepatic tissues. The conversion of fatty acids to cholesterol via the KBs may be a particularly important example of lipid interconversion. Utilizing KBs for lipid synthesis is glucose sparing and probably is important with low carbohydrate diets. Metabolic situations and tissues where lipid interconversion may be important are discussed.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
白鸽鸽完成签到,获得积分10
刚刚
刚刚
737发布了新的文献求助10
1秒前
2秒前
3秒前
酷波er应助阿庆采纳,获得10
4秒前
哈尼发布了新的文献求助10
4秒前
5秒前
5秒前
欧阳蛋蛋鸡完成签到 ,获得积分10
6秒前
coco完成签到 ,获得积分10
6秒前
8秒前
8秒前
LiJing666发布了新的文献求助10
8秒前
ling_lz发布了新的文献求助10
8秒前
科研通AI5应助路遥知马力采纳,获得10
10秒前
乐乐应助大方小白采纳,获得10
11秒前
WxChen发布了新的文献求助10
11秒前
GGBond完成签到 ,获得积分10
13秒前
15秒前
LiJing666完成签到,获得积分10
15秒前
忧伤的雅香完成签到,获得积分10
19秒前
今后应助酸柠檬本檬采纳,获得30
19秒前
kate发布了新的文献求助10
22秒前
22秒前
科研通AI2S应助liuxh123采纳,获得10
22秒前
王特工完成签到,获得积分10
23秒前
科研通AI5应助柠檬加冰采纳,获得10
23秒前
科研通AI5应助L.采纳,获得10
24秒前
25秒前
三脸茫然完成签到 ,获得积分10
25秒前
26秒前
洁净缘分完成签到 ,获得积分10
26秒前
彩虹猫完成签到 ,获得积分10
26秒前
路遥知马力完成签到,获得积分10
27秒前
zcious发布了新的文献求助10
27秒前
28秒前
Jasper应助科研通管家采纳,获得10
28秒前
大模型应助科研通管家采纳,获得10
28秒前
隐形曼青应助科研通管家采纳,获得30
28秒前
高分求助中
Applied Survey Data Analysis (第三版, 2025) 800
Narcissistic Personality Disorder 700
Assessing and Diagnosing Young Children with Neurodevelopmental Disorders (2nd Edition) 700
The Elgar Companion to Consumer Behaviour and the Sustainable Development Goals 540
The Martian climate revisited: atmosphere and environment of a desert planet 500
Images that translate 500
Transnational East Asian Studies 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3843657
求助须知:如何正确求助?哪些是违规求助? 3385947
关于积分的说明 10543274
捐赠科研通 3106748
什么是DOI,文献DOI怎么找? 1711147
邀请新用户注册赠送积分活动 823921
科研通“疑难数据库(出版商)”最低求助积分说明 774390