Risk Factors of Medication-Related Osteonecrosis of the Jaw: A Clinical Investigation

德诺苏马布 医学 颌骨骨坏死 入射(几何) 恶性肿瘤 骨质疏松症 不利影响 阶段(地层学) 内科学 疾病 外科 双膦酸盐 古生物学 物理 光学 生物
作者
Yuko Komatsu,Tadashi Kawai,Taifu Hirano,Isao Hoshi,Genki Yamaya,Atsushi Ogawa,Toshimi Chiba,Hiroyuki Yamada
出处
期刊:Journal of Stomatology, Oral and Maxillofacial Surgery [Elsevier BV]
卷期号:125 (6): 101791-101791 被引量:3
标识
DOI:10.1016/j.jormas.2024.101791
摘要

Medication-related osteonecrosis of the jaw (MRONJ) is an intractable condition caused by drugs such as bisphosphonates and denosumab. This study investigated the changes in the incidence of MRONJ in the previous 10 years and examined the poor prognostic factors during surgery in at-risk patients. We compared 57 and 64 patients diagnosed with MRONJ at our hospital between January 2012 and December 2016 and January 2017 and December 2021, respectively. The disease stage and triggers at the time of initial diagnosis in eligible patients were investigated. Additionally, the adverse prognostic factors were examined in 166 patients at risk of MRONJ who underwent tooth extraction at our department during these 10 years. The results indicated that there was no change in the proportion of patients with osteoporosis and malignancy among those with MRONJ. The number of cases after tooth extraction decreased, and those after dental infections increased on comparing the recent 5 years and the preceding 5 years. The number of MRONJ patients receiving denosumab also increased. Denosumab was a significant post-extraction prognostic factor for delayed healing in the 166 patients at risk of MRONJ. The findings suggest that patients receiving denosumab should be closely monitored when undergoing surgery to prevent MRONJ.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
wzy关注了科研通微信公众号
刚刚
开心夏天完成签到,获得积分10
1秒前
青山完成签到,获得积分10
1秒前
woshiwuziq发布了新的文献求助10
1秒前
Jasper应助hyman采纳,获得10
2秒前
君临梅阿查完成签到,获得积分10
2秒前
MaYue完成签到,获得积分10
2秒前
无私幼蓉发布了新的文献求助10
3秒前
4秒前
陈JY完成签到 ,获得积分10
4秒前
青山发布了新的文献求助30
4秒前
4秒前
小木得霖完成签到,获得积分10
5秒前
5秒前
6秒前
冯微微发布了新的文献求助10
6秒前
研沫儿发布了新的文献求助10
6秒前
6秒前
QXR完成签到,获得积分10
7秒前
acuis发布了新的文献求助10
8秒前
小猫宝发布了新的文献求助10
9秒前
9秒前
妮妮发布了新的文献求助10
10秒前
小羊zhou发布了新的文献求助10
10秒前
大模型应助蓝岳洋采纳,获得10
12秒前
wangdong完成签到,获得积分0
13秒前
充电宝应助Berserker采纳,获得10
13秒前
kk完成签到,获得积分10
14秒前
清脆雅绿完成签到 ,获得积分10
14秒前
15秒前
旭日发布了新的文献求助10
15秒前
lhn完成签到 ,获得积分10
15秒前
@A完成签到,获得积分10
16秒前
16秒前
17秒前
17秒前
可靠的魔镜完成签到,获得积分10
18秒前
浅池星发布了新的文献求助30
20秒前
20秒前
KD发布了新的文献求助10
22秒前
高分求助中
Mass producing individuality 600
Algorithmic Mathematics in Machine Learning 500
Разработка метода ускоренного контроля качества электрохромных устройств 500
Getting Published in SSCI Journals: 200+ Questions and Answers for Absolute Beginners 300
Advances in Underwater Acoustics, Structural Acoustics, and Computational Methodologies 300
Worked Bone, Antler, Ivory, and Keratinous Materials 200
The Physical Oceanography of the Arctic Mediterranean Sea 200
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3828040
求助须知:如何正确求助?哪些是违规求助? 3370323
关于积分的说明 10462906
捐赠科研通 3090294
什么是DOI,文献DOI怎么找? 1700312
邀请新用户注册赠送积分活动 817813
科研通“疑难数据库(出版商)”最低求助积分说明 770458