败血症
操作分类学单元
微生物群
失调
肠道菌群
内科学
感染性休克
生物
医学
免疫学
生理学
生物信息学
16S核糖体RNA
细菌
遗传学
作者
Se Ju Lee,Dajeong Kim,Hea Won Ann,Man Jung Han,Jung Ah Lee,Yongseop Lee,Sang-Hoon Ahn,Hwi Won Seo,Jung Ho Kim,Jin Young Ahn,Su Jin Jeong,Nam Su Ku,Joon‐Sup Yeom,Choong-Min Ryu,Jun Yong Choi
出处
期刊:Shock
[Ovid Technologies (Wolters Kluwer)]
日期:2023-10-06
被引量:1
标识
DOI:10.1097/shk.0000000000002241
摘要
Abstract Introduction Gut microbiota dysbiosis is associated with susceptibility to sepsis and poor outcomes. However, changes to the intestinal microbiota during sepsis and their value as biomarkers are unclear. In this study, we compared the intestinal microbiota of patients with sepsis and healthy controls. Methods Stool was collected from patients with sepsis (subdivided according to mortality) and controls. Microbiome diversity and composition were analyzed by 16S rRNA gene pyrosequencing. The α-diversity of the intestinal microbiome was determined using operational taxonomic unit (OTU) counts and the Chao1, Shannon, and ACE indices. Adjusted Cox regression analyses assessed 6-month mortality risk factors. Results Fifty-nine patients (14 in-hospital deaths) and 29 healthy controls were enrolled. OTU counts and Chao1 and ACE indices were lower in the non-survivor than in the other groups. The controls showed a higher Shannon and lower Simpson index than did the sepsis group. The genus Blautia was more abundant in controls than in the sepsis group, and Faecalibacterium less abundant in the non-survivor than in the other groups. Regression analysis associated low Shannon index with 6-month mortality. Conclusions Survivors of sepsis, non-survivors, and healthy controls have different gut microbiomes, and a low Shannon index is a risk factor for 6-month mortality.
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