结晶
动力学
形态学(生物学)
过程(计算)
化学工程
材料科学
工艺优化
化学
工艺工程
计算机科学
工程类
地质学
物理
古生物学
量子力学
操作系统
作者
Rui Han,Yuxin Li,Shengzhe Jia,Tiantian Tao,Yaoguo Wang,Lishan Zhou,Xinfa Li,Chuanxi Zhu,Qiujian Lv,Weiwei Tang,Junbo Gong
标识
DOI:10.1016/j.powtec.2024.119715
摘要
The important intermediate thiothiamine for Vitamin B1 production is often challenged by issues related to mixed polymorphs and needle-shaped crystal morphology in industrial production. These challenges can be effectively addressed through crystal engineering strategies. In this study, the key factors affecting the crystal form were investigated in reactive crystallization. Subsequently, the reactive crystallization process was monitored online using in-situ ATR-FTIR and FBRM techniques. It was determined that crystallization process is the rate-limiting step throughout the reactive crystallization process. Various factors affecting the crystal morphology were identified. Through process control and optimization, a product was achieved with a filtration time reduced by over 60% and a moisture content reduction of >20%. Overall, this study provides valuable insights from a crystal engineering perspective to address the poor powder properties.
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