Severe mixed hypersensitivity reaction induced by antivenom: diagnostic challenges and precision management

This represents the first documented case of severe mixed hypersensitivity (co-occurring Type I anaphylaxis and Type III serum sickness) triggered by antivenom. It highlights the diagnostic challenge posed by overlapping biphasic features and multi-system involvement occurring within the typical serum sickness window. Precision management addressing both pathogenic pathways simultaneously, specifically via combined hemodynamic stabilization, anti-inflammatory therapy, and volume support, was critical for successful recovery. Enhanced vigilance for this synergistic reaction pattern is warranted.