Cocklebur-inspired magnetic nanomotors for targeted thrombus therapy

study proves that these cocklebur-like nanomotors can successfully treat a mouse model with a reduced thrombus area of 3.3-fold compared with direct-injection of rt-PA. Also, the coagulation system exhibits no obvious changes. All the results confirm the synergistic effect of magnetic control, adherence, and targeted drug release. These features suggest that the efficient thrombolysis ability of these nanomotors could offer new therapeutic strategies and practical value for cardiac, cerebral, and peripheral thrombotic diseases.