Mechanisms of di (2‐Ethylhexyl) Phthalate‐Induced Lipid Metabolism Disorders: A Review

ABSTRACT Di(2‐ethylhexyl) phthalate (DEHP) is a widely used plasticizer that can be absorbed by the human body through various pathways. Numerous studies have indicated the adverse effects of DEHP on lipid metabolism. Experimental and population studies have provided evidence for DEHP‐induced lipid metabolism disorder. This review discusses the cellular pathophysiological changes leading to lipid metabolism disorders, including inflammation, apoptosis, autophagy, and oxidative stress. We also summarize the key molecules and signaling pathways involved in the lipid metabolism disorder induced by DEHP. Additionally, multiple omics such as metabolomics, transcriptomics, and epigenetics are discussed in this review. Furthermore, this article provides some directions for future research about the mechanisms of lipid metabolism disorders caused by DEHP, aiming to offer more detailed and reliable theoretical evidence for the prevention and treatment of lipid metabolism disorders.