Soufeng Sanjie formula alleviates the progression of lupus and joint injury by regulating the ALKBH5-FoxO1-PFKFB3 axis in M-MDSCs

This study confirmed that SF enhanced glycolysis in M-MDSCs by regulating the ALKBH5-FoxO1-PFKFB3 axis, which decreased Th17 cells and alleviated lupus and joint injury. These data firstly indicate SF may represent a potential treatment option for SLE and joint damage, revealing regulatory effects of DP, the key active component of SF, at the post-transcriptional level.