下调和上调
细胞生物学
多嘧啶结合蛋白
谷氨酸受体
神经发生
化学
选择性拼接
神经科学
生物
生物化学
基因
信使核糖核酸
受体
作者
Yan Liu,Jian Ren,Wenlong Zhang,Liuyan Ding,Runfang Ma,Mengran Zhang,Shaohui Zheng,Ruijing Liang,Yunlong Zhang
出处
期刊：Biomaterials
[Elsevier BV]
日期：2024-07-20
卷期号：312: 122707-122707
被引量：6
标识
DOI：10.1016/j.biomaterials.2024.122707
摘要
Polypyrimidine tract-binding protein 1 (PTBP1) regulates numerous alternative splicing events during tumor progression and neurogenesis. Previously, PTBP1 downregulation was reported to convert astrocytes into functional neurons; however, how PTBP1 regulates astrocytic physiology remains unclear. In this study, we revealed that PTBP1 modulated glutamate uptake via ATP1a2, a member of Na
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