77P Hypermethylation of genes HIST1H4F, Septin9 and RASSF1 as the potential biomarker for nasopharyngeal carcinoma screening

Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumors in Southeast Asia, especially in southern China. There were about 129,000 new NPC cases and 34,000 deaths worldwide in 2018 according to Global Cancer Obsercatory. Even though NPC is sensitive to radiotherapy and has a 5-year survival rate of about 70%, the prognosis is poor in advanced stage. Therefore, it is important to screen NPC in the early stage. Epstein–Barr virus (EBV) infection plays important roles in the development of NPC, and EBV immunological assay is employed as a standard diagnostics of NPC, however, it is an invasive method.