小分子
机制(生物学)
作用机理
药品
药物重新定位
计算生物学
药理学
医学
药物发现
生物
化学
生物信息学
生物化学
认识论
哲学
体外
作者
Gaye Saginc,Franziska Voellmy,Rune Linding
标识
DOI:10.1038/nchembio.2519
摘要
The 'off-targets' of a drug are often poorly characterized yet could be harnessed in the treatment of complex diseases. A recent study used a small-molecule screening in non-small-cell lung cancer to repurpose an FDA-approved ALK/IGF1R inhibitor and uncover its mechanism of action.
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