伤口愈合
体内
再生(生物学)
明胶
体外
干细胞
伤口敷料
生物医学工程
脂肪生成
脂肪组织
材料科学
医学
生物
细胞生物学
外科
生物技术
内科学
复合材料
生物化学
作者
Li‐Han Hsu,Bou Yue Peng,May Show Chen,Bahruddin Thalib,Muhammad Ruslin,Tran Dang Xuan Tung,Hsiu‐Chu Chou,Keng Liang Ou
摘要
Abstract In this study, the wound healing properties of the gelatin‐based hydrogel (GBH) wound dressing combined with adipose‐derived stem cells (ADSCs) were investigated using the mouse and porcine models. The analytical results showed that the ADSCs harvested from the porcine significantly increased cell growth and promoted cell differentiation (adipogenesis and osteogenesis) in comparison to the ADSCs harvested from the mouse in vitro . Moreover, the in vivo results also indicated that the GBH wound dressing combined with ADSCs and its culture medium could potentially accelerate wound healing in the mouse and porcine models. The ADSCs presented a possibility of recovery from wounds and injuries through skin regeneration. Therefore, both in vitro and in vivo results demonstrated that the ADSCs can potentially be an effective clinical treatment through the GBH wound dressing, which is a promising evidence‐based complementary and alternative medicine for skin regeneration. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 107B: 278–285, 2019.
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