分解代谢
细胞生物学
化学
间充质干细胞
细胞外基质
基质
伤口愈合
肿瘤进展
炎症
细胞生长
细胞
细胞凋亡
癌症研究
肿瘤微环境
新陈代谢
透明质酸合成酶
生物化学
生物
糖胺聚糖
透明质酸
免疫学
肿瘤细胞
基因
免疫组织化学
遗传学
作者
Markku Tammi,Sanna Oikari,Sanna Pasonen‐Seppänen,Kirsi Rilla,Päivi Auvinen,Raija Tammi
出处
期刊:Matrix Biology
[Elsevier]
日期:2019-05-01
卷期号:78-79: 147-164
被引量:72
标识
DOI:10.1016/j.matbio.2018.04.012
摘要
Hyaluronan accumulates in the stroma of several solid tumors and promotes their progression. Both enhanced synthesis and fragmentation of hyaluronan are required as a part of this inflammatory process resembling wound healing. Increased expression of the genes of hyaluronan synthases (HAS1-3) are infrequent in human tumors, while posttranslational modifications that activate the HAS enzymes, and glucose shunted to the UDP-sugar substrates HASs, can have crucial contributions to tumor hyaluronan synthesis. The pericellular hyaluronan influences virtually all cell-cell and cell-matrix interactions, controlling migration, proliferation, apoptosis, epithelial to mesenchymal transition, and stem cell functions. The catabolism by hyaluronidases and free radicals appears to be as important as synthesis for the inflammation that promotes tumor growth, since the receptors mediating the signals create specific responses to hyaluronan fragments. Targeting hyaluronan metabolism shows therapeutic efficiency in animal experiments and early clinical trials.
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