Expression and significance of Ephb4 in esophageal cancer

Objective:To determine the biological significance of expression of Ephb4 in esophageal cancer. Methods:The expression of Ephb4 was detected in 50 esophageal cancer tissues by immunohischemical method(s-p) and 20 normal esophageal tissues as control. Results:Ephb4 protein was detectable in 60.0% of all 50 esophageal cancer,in the normal esophageal tissues,the expression was negative,the difference was significant(P0.01);The positive rate of the expression of Ephb4 was significantly related to histological differentiation and clinical stages of esophageal cancer(P0.05); but had no significant relationship with histological classification and lymphoid metastasis(P0.05).Conclusion:Ephb4 was overexpressed in esophageal cancer and it was related to the advancement and malignant behavior of esophageal cancer. Ephb4 may play promotion role in the development of esophageal cancer and it may be a reference index in prognosis and treatment assessment.