诱导多能干细胞
体细胞
胚胎干细胞
再生医学
生物
表观遗传学
干细胞
细胞生物学
重编程
细胞
遗传学
基因
作者
Young Doug Sohn,Ji Yun Han,Young Sup Yoon
出处
期刊:Progress in Molecular Biology and Translational Science
日期:2012-01-01
卷期号:: 1-26
被引量:16
标识
DOI:10.1016/b978-0-12-398459-3.00001-0
摘要
The technology for generation of induced pluripotent stem cell (iPSC) from somatic cells emerged to circumvent the ethical and immunological limitations of embryonic stem cell (ESC). The recent progress of iPSC technology offers an unprecedented tool for regenerative medicine; however, integrating viral-driven iPSCs prohibits clinical applications by their genetic alterations and tumorigenicity. Various approaches including nonintegrating, nonviral, and nongenetic methods have been developed for generating clinically compatible iPSCs. In addition, approaches for using more clinically convenient or compatible source cells replacing fibroblasts have been actively pursued. While iPSC and ESC closely resemble in genomic, cell biologic, and phenotypic characteristics, these two pluripotent stem cells are not identical in terms of differentiation capacity and epigenetic features. In this chapter, we deal with the current techniques of generating iPSCs and their various characteristics.
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