Paraoxonase Family's Biological Characters and Its Relationship with Diseases

The paraoxonase family consists of three members(PON1,PON2 and PON3)that shape structural properties and enzymatic activities,among which is the ability to hydrolyze oxidized lipids in LDL.There is a relationship between its antioxidant ability and many diseases.Up to date,it is proved that PON1 activity inhibits the development of cardio-vascular diseases such asarteriosclerosis(AS)and coronary heart disease(CHD).But the influence of PON gene polymorphlisms is still uncertain in the terms of diabetes mellitus.Besidesgene polymorphlisms,smoking can decrease the concentration and activity of PON,while the influence of alcohol depends on its amount.In addition,more studies should be taken to identify the roles of factors such as vitamin E in regulating the paraoxonase.