α-Glucosidase Inhibitory Activity of Salvia honania L.H.Bailey in vivo and vitro

The yeast and rat intestinal α-glucosidase inhibitory activity of Salvia.honania was assayed by the method of 96-microplates for the first time.Yeast α-glucosidase inhibitory activity of ethyl acetate extracts(IC50 =28.73 μg/mL) and n-butanol extracts of S.honania(IC50 =73.90 μg/mL) were higher than that of Acarbose(IC50=1081.27 μg/mL) as positive control.Only ethyl acetate extracts(IC50 =366.79 μg/mL) showed inhibitory activity on rat intestinal α-glucosidase,and the IC50 value of Acarbose was not detected.The results indicated that both ethyl acetate extracts and n-butanol extracts of S.honania showed a better yeast α-glucosidase inhibitory activity,but only ethyl acetate extracts showed a better rat intestinal α-glucosidase inhibitory activity.