Tenofovir Alafenamide May Offer Safety Benefit over Tenofovir Disoproxil Fumarate

Because of its safety and efficacy, tenofovir disoproxil fumarate (TDF) is an important component of many key antiretroviral therapy regimens, despite concerns about renal and bone toxicity with long-term use. Tenofovir alafenamide (TAF) addresses some of those concerns, in part because the plasma levels needed to maintain antiviral efficacy are lower. In a recent manufacturer-funded, phase II, …