A case of acromegaly accompanied by pituitary adenoma in a 35-year-old male is reported. The patient presented with mandibular protrusion, malocclusion and articulate disorder. Prior to oral surgery, a pituitary adenoma was resected at the Department of Neurosurgery. Pre-operative orthodontic treatment was started after growth hormone and insulin-like growth factor I had returned to normal levels. Orthognathic surgery by sagittal split ramus osteotomy (SSRO) was performed, and good occlusion was obtained. Articulate function also improved after orthognathic surgery.