Advances in research on chronic active Epstein-Barr virus infection

Chronic active Epstein -Barr virus (CAEBV) infection is an uncommon outcome of Epstein-Barr virus infection and may present as severe or fulminant syndrome with high-mortality. The clinical manifestation of CAEBVI is diverse and various organs may be involved. It was characterized by chronic or recurrent infectious mononucleosis-like symptoms persisting over a long time and by an unusual pattern of anti-EBV antibodies or high viral load. Although it occurs in immunocompetent individuals, subtle underlying immunodeficiency may exist in patients with CAEBV. This review focuses on CAEBV regarding its pathogenic mechanisms, clinical manifestation, diagnosis, and treatment strategies.