Atypical Kinetics of Valproic Acid Glucuronidation In vitro and In vivo in Humans

Atypical kinetics has been observed in vitro for both cytochrome P450 and UDP-glucuronosyltransferase catalyzed enzymatic reactions. The in vitro and in vivo kinetics of valproic acid-glucuronide (VPA-glucuronide) formation was investigated in humans.