Clinical Significance of Bmi1 Expression in Inflammatory Bowel Disease

体重指数1 医学 炎症性肠病 结直肠癌 肿瘤坏死因子α 溃疡性结肠炎 炎症 下调和上调 结肠炎 癌症 临床意义 肠粘膜 内科学 免疫学 疾病 癌症研究 生物 基因 生物化学
作者
Mitsunari Yamada,Toshiharu Sakurai,Yoriaki Komeda,Tomoyuki Nagai,Ken Kamata,Kosuke Minaga,Kentaro Yamao,Mamoru Takenaka,Satoru Hagiwara,Shigenaga Matsui,Tomohiro Watanabe,Naoshi Nishida,Hiroshi Kashida,Masatoshi Kudo
出处
期刊:Oncology [Karger Publishers]
卷期号:93 (Suppl. 1): 20-26 被引量:9
标识
DOI:10.1159/000481225
摘要

Although the stem cell marker Bmi1 is overexpressed in many malignancies, its role in inflammation-associated cancer is unclear. Colitis-associated cancer (CAC) is caused by chronic intestinal inflammation and often results from refractory inflammatory bowel disease (IBD).To assess the involvement of Bmi1 in the development of CAC, we analyzed the gene expression of colon tissues collected from 111 patients with IBD and CAC.In the colonic mucosa of patients with ulcerative colitis, the expression of Bmi1 correlated significantly with the expression of inflammatory cytokines such as IL-6, IL-17, IL-23, and tumor necrosis factor α (TNF-α). In the colonic mucosa of patients with Crohn's disease, the expression of Bmi1 correlated significantly with the expression of TNF-α and IL-23. The expression of Bmi1 was enhanced in the colonic mucosae of refractory IBD, suggesting that Bmi1 expression might be related to increased cancer risk. In addition, patients with high Bmi1 expression showed significantly lower response rates upon subsequent anti-TNF-α therapy as compared to patients with low Bmi1 expression. In human CAC specimens, the expression of Bmi1 was upregulated in nontumor tissues as well as tumors.Bmi1 expression is related to a refractory clinical course of IBD and upregulated in refractory IBD and CAC. Measurement of Bmi1 expression is a promising approach for the advanced treatment and personalized management of IBD patients.

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