医学
心脏病学
内科学
冠状窦
血流动力学
血管舒张
血管阻力
微循环
血流
刺激
血压
冠状动脉循环
麻醉
作者
B Kaada,Harald Vik‐Mo,Gunnar Alm Rosland,Leik Woie,P. K. Opstad
标识
DOI:10.1093/oxfordjournals.eurheartj.a059728
摘要
Low-frequency transcutaneous nerve stimulation (TNS) is known to produce widespread and prolonged vasodilation in skin and muscles. In the present study the effects of low-frequency TNS on coronary and systemic haemodynamics, myocardial blood flow, myocardial oxygen consumption, myocardial free fatty acid andlactate uptake were measured at rest in 16 normotensive patients, with coronary heart disease, undergoing diagnostic cardiac catheterization. In addition, vasoactive intestinal polypeptides (VIP) and noradrenaline were measured in the coronary sinus and the aorta. The study was randomized and double-blind, with half of the patients serving as placebo controls. A stimulation period of 20 min caused a significant lowering of mean femoral arterial pressure and systemic vascular resistance measured at 15 and 30 min after the start of TNS (P<0–01). There was no significant change in the other parameters mentioned. The hypotonic effect is considered to be due to increased peripheral microcirculation resulting from sympatho-inhibition.
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