神经刺激
神经生理学
脑瘫
物理医学与康复
约束诱导运动疗法
冲程(发动机)
临床神经生理学
临床试验
脑深部刺激
脑刺激
心理学
医学
物理疗法
刺激
帕金森病
神经科学
脑电图
运动功能
疾病
内科学
机械工程
工程类
作者
Hsing‐Ching Kuo,Jennifer Litzenberger,Alberto Nettel-Aguirre,Ephrem Zewdie,Adam Kirton
标识
DOI:10.1080/17518423.2021.1964103
摘要
Perinatal stroke causes hemiparetic cerebral palsy (HCP) and lifelong disability. Constraint-induced movement therapy (CIMT) and neurostimulation may enhance motor function, but the individual factors associated with responsiveness are undetermined.We explored the clinical and neurophysiological factors associated with responsiveness to CIMT and/or brain stimulation within a clinical trial.PLASTIC CHAMPS was a randomized, blinded, sham-controlled trial (n = 45) of CIMT and neurostimulation paired with intensive, goal-directed therapy. Primary outcome was the Assisting Hand Assessment (AHA). Classification trees created through recursive partitioning suggested clinical and neurophysiological profiles associated with improvement at 6-months.Both clinical (stroke side (left) and age >14 years) and neurophysiological (intracortical inhibition/facilitation and motor threshold) were associated with responsiveness across treatment groups with positive predictive values (PPV) approaching 80%.This preliminary analysis suggested sets of variables that may be associated with response to intensive therapies in HCP. Further modeling in larger trials is required.
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