谷胱甘肽
抗氧化剂
氧化应激
胞浆
线粒体
生物化学
内质网
氧化磷酸化
化学
过氧化物酶体
活性氧
细胞内
甘氨酸
细胞生物学
生物
酶
氨基酸
基因
作者
Sristi Raj,Camelia Bhattacharyya,Anwita Sarkar,Surupa Chakraborty,Esha Sircar,Sreejita Dutta,Rajib Sengupta
标识
DOI:10.1002/slct.202100773
摘要
Abstract Glutathione (GSH) is the most abundant cellular tripeptide (L‐γ‐glutamate‐L‐cysteinyl‐glycine) which is as critical as oxygen and water. This low molecular mass antioxidant has a very high intracellular concentration that ranges from 1–10 mM and reaches extreme concentration points in malignant cell types. This defender of the cell is compartmentalized in mitochondria, nucleus, peroxisomes, endoplasmic reticulum (ER), and cytosol where it is synthesized. The enzymes involved in GSH redox cycling are important for both cellular free radical and non‐radical detoxification. The present review article is covering the crucial roles of GSH to combat oxidative/nitrosative stress related to different diseases/disorders and possible drug designing for new therapies.
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