STING1 exacerbates iodinated contrast-induced acute kidney injury by promoting ferroptosis through chaperone-mediated autophagic degradation of FTH1

3-MA: 3-methyladenine; AIFM2/FSP1: AIF family member 2, ferroptosis suppressor; CLBD: cytoplasmic ligand-binding domain; CGAS: cyclic GMP-AMP synthase; CI-AKI: contrast-induced acute kidney injury; CMA: chaperone-mediated autophagy; CQ: chloroquine; CTT: C-terminal tail; DHE: dihydroethidium; FTH1: ferritin heavy chain 1; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GPX4: glutathione peroxidase 4; GSH/GSSG: glutathione/glutathione oxidized; KO: knockout; HK-2 cell: human renal proximal tubular epithelial cell; HSPA8/HSC70: heat shock protein family A (Hsp70) member 8; IRI: ischemia-reperfusion injury; KFERQ: CMA recognition pentapeptide; LAMP2A: lysosomal associated membrane protein 2A; MDA: malondialdehyde; NCOA4: nuclear receptor coactivator 4; PT: proximal tubule; RPTCs: renal proximal tubule cells; ROS: reactive oxygen species; STING1: stimulator of interferon response cGAMP interactor 1; TMD: transmembrane domain; WT: wild-type.