Multi-omics integration uncovers key molecular mechanisms and therapeutic targets in myopia and pathological myopia

Our multi-omics framework prioritizes PDGFRA, LRRTM2, and PCOLCE as candidates linked to ECM remodeling, neurotransmission, and scleral biomechanics in myopia and PM. Integrating MR with colocalization, PPI, and pathway analyses yields mechanistic hypotheses and testable targets. Docking/MD findings are exploratory and will require experimental validation before any therapeutic inference.