GRADE misuse in systematic reviews – Authors' reply

We would like to thank Meng Lv and colleagues for their feedback on our systematic review.1 Their Correspondence queried our assessment of the level of evidence of the included studies, which was done according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.2 GRADE is supported by the Cochrane Handbook for Systematic Reviews of Interventions and provides a framework for rating the quality of studies, presenting a summary of findings, and developing recommendations.