阿比坦
萜类
立体化学
化学
二萜
环氧树脂
有机化学
作者
Xing Peng,Qingyun Tan,Leiming Wu,De‐Yin Wu,Jing Xu,Huihao Zhou,Qiong Gu
标识
DOI:10.1021/acs.jnatprod.2c00352
摘要
Two new 3,4-epoxy group-containing abietane diterpenoids (1 and 2), together with five known diterpenoids (3–7), were isolated from Ajuga decumbens. Their structures were elucidated by spectroscopic data analysis, NMR calculations, and X-ray diffraction experiments. The structures of two known abietane diterpenoids were revised based on NMR calculations and X-ray diffraction data. Notably, compound 4 specifically inhibited RSL3-induced ferroptosis with an EC50 of 56 nM by antioxidation. Moreover, 4 significantly decreased RSL3-induced lipid and cytosolic ROS accumulation and ferroptosis marker gene PTGS2 mRNA expression. This work reports the most potent natural inhibitor against ferroptosis found so far.
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