动脉瘤
蛛网膜下腔出血
医学
剪裁(形态学)
脑血管痉挛
放射科
外科
血管痉挛
语言学
哲学
作者
John W. Thompson,Omar Elwardany,David McCarthy,Dallas Sheinberg,Carlos M. Alvarez,Ahmed Nada,Brian Snelling,Stephanie H. Chen,Samir Sur,Robert M. Starke
出处
期刊:Neurosurgical Focus
[Journal of Neurosurgery Publishing Group]
日期:2019-07-01
卷期号:47 (1): E20-E20
被引量:31
标识
DOI:10.3171/2019.4.focus19219
摘要
Cerebral aneurysm rupture is a devastating event resulting in subarachnoid hemorrhage and is associated with significant morbidity and death. Up to 50% of individuals do not survive aneurysm rupture, with the majority of survivors suffering some degree of neurological deficit. Therefore, prior to aneurysm rupture, a large number of diagnosed patients are treated either microsurgically via clipping or endovascularly to prevent aneurysm filling. With the advancement of endovascular surgical techniques and devices, endovascular treatment of cerebral aneurysms is becoming the first-line therapy at many hospitals. Despite this fact, a large number of endovascularly treated patients will have aneurysm recanalization and progression and will require retreatment. The lack of approved pharmacological interventions for cerebral aneurysms and the need for retreatment have led to a growing interest in understanding the molecular, cellular, and physiological determinants of cerebral aneurysm pathogenesis, maturation, and rupture. To this end, the use of animal cerebral aneurysm models has contributed significantly to our current understanding of cerebral aneurysm biology and to the development of and training in endovascular devices. This review summarizes the small and large animal models of cerebral aneurysm that are being used to explore the pathophysiology of cerebral aneurysms, as well as the development of novel endovascular devices for aneurysm treatment.
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