一氧化氮
活性氧
药物输送
氧气
氧气输送
药品
化学
超声波
生物物理学
药理学
医学
生物化学
生物
有机化学
放射科
作者
Ruiqi Wu,Wei Yuan,Shijie Sun,Qinglian Tang,Jinxia Zhang,Chaoyi Chen,Shanshan Xu,Xiaotu Ma,Xiaolong Liang
标识
DOI:10.1016/j.cej.2024.150134
摘要
Liposomal drug delivery for tumor therapy was still suffered from low stability, limited delivering efficiency and poor tumor penetration, greatly compromising the therapeutic efficacy. Herein, a stable and ultrasound triggered cerasomal delivery system was developed by loading doxorubicin (DOX) into stable liposomal cerasome, which was self-assembled from cerasome-forming lipid (C), sonosensitizer of porphyrin lipid (P), nitric oxide (NO) donor of DSPE-PEG2000-SNO (SNO) and unsaturated phospholipids DOPC, resulting in DOX@PC-SNO with stable siloxane network and S-nitrosothiol on surface, sonosensitizer in lipid bilayer and DOX in the core. DOX@PC-SNO can prevent drug leakage during blood circulation and efficiently accumulation at the tumor site at 24 h post-injection, while controllably generate reactive oxygen species (ROS) upon local ultrasound irradiation on tumor, which can not only use for SDT, but also operate as a switch for on-demand controlled release of internal DOX and external NO, resulting in specific delivery and high penetration of chemotherapeutic drug into the deep tumor, greatly improved antitumor efficacy without observed side effects.
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