胞吐
厌恶性刺激
谷氨酸受体
神经科学
联想学习
气味
蘑菇体
条件作用
细胞生物学
化学
生物
生物物理学
心理学
黑腹果蝇
受体
生物化学
分泌物
基因
统计
数学
作者
Tomoyuki Miyashita,Kanako Murakami,Emi Kikuchi,Kyouko Ofusa,Kyohei Mikami,Kentaro Endo,Takaaki Miyaji,Sawako Moriyama,Kohtarou Konno,Hiromi Muratani,Yoshinori Moriyama,Masahiko Watanabe,Junjiro Horiuchi,Minoru Saitoe
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2023-12-22
卷期号:382 (6677)
标识
DOI:10.1126/science.adf7429
摘要
During Drosophila aversive olfactory conditioning, aversive shock information needs to be transmitted to the mushroom bodies (MBs) to associate with odor information. We report that aversive information is transmitted by ensheathing glia (EG) that surround the MBs. Shock induces vesicular exocytosis of glutamate from EG. Blocking exocytosis impairs aversive learning, whereas activation of EG can replace aversive stimuli during conditioning. Glutamate released from EG binds to N -methyl- d -aspartate receptors in the MBs, but because of Mg 2+ block, Ca 2+ influx occurs only when flies are simultaneously exposed to an odor. Vesicular exocytosis from EG also induces shock-associated dopamine release, which plays a role in preventing formation of inappropriate associations. These results demonstrate that vesicular glutamate released from EG transmits negative valence information required for associative learning.
科研通智能强力驱动
Strongly Powered by AbleSci AI