清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

89Zr-panitumumab Combined With 18F-FDG PET Improves Detection and Staging of Head and Neck Squamous Cell Carcinoma

医学 头颈部鳞状细胞癌 头颈部癌 活检 核医学 正电子发射断层摄影术 放射科 PET-CT 帕尼单抗 置信区间 癌症 内科学 克拉斯 结直肠癌
作者
Y.-J. Lee,Nynke S. van den Berg,Heying Duan,E. Carmen Azevedo,Valentina Ferri,Marisa E. Hom,Roan C. Raymundo,Alex Valencia,Jessa B. Castillo,Bin Shen,Quan Zhou,Laura E. Beane Freeman,Mary Ellen I. Koran,Michael J. Kaplan,A. Dimitrios Colevas,Fred M. Baik,Frederick T. Chin,Brock A. Martin,Andrei Iagaru,Eben L. Rosenthal
出处
期刊:Clinical Cancer Research [American Association for Cancer Research]
卷期号:28 (20): 4425-4434 被引量:12
标识
DOI:10.1158/1078-0432.ccr-22-0094
摘要

Abstract Purpose: Determine the safety and specificity of a tumor-targeted radiotracer (89Zr-pan) in combination with 18F-FDG PET/CT to improve diagnostic accuracy in head and neck squamous cell carcinoma (HNSCC). Experimental Design: Adult patients with biopsy-proven HNSCC scheduled for standard-of-care surgery were enrolled in a clinical trial and underwent systemic administration of 89Zirconium-panitumumab and panitumumab-IRDye800 followed by preoperative 89Zr-pan PET/CT and intraoperative fluorescence imaging. The sensitivity, specificity, and AUC were evaluated. Results: A total of fourteen patients were enrolled and completed the study. Four patients (28.5%) had areas of high 18F-FDG uptake outside the head and neck region with maximum standardized uptake values (SUVmax) greater than 2.0 that were not detected on 89Zr-pan PET/CT. These four patients with incidental findings underwent further workup and had no evidence of cancer on biopsy or clinical follow-up. Forty-eight lesions (primary tumor, LNs, incidental findings) with SUVmax ranging 2.0–23.6 were visualized on 18F-FDG PET/CT; 34 lesions on 89Zr-pan PET/CT with SUVmax ranging 0.9–10.5. The combined ability of 18F-FDG PET/CT and 89Zr-pan PET/CT to detect HNSCC in the whole body was improved with higher specificity of 96.3% [confidence interval (CI), 89.2%–100%] compared to 18F-FDG PET/CT alone with specificity of 74.1% (CI, 74.1%–90.6%). One possibly related grade 1 adverse event of prolonged QTc (460 ms) was reported but resolved in follow-up. Conclusions: 89Zr-pan PET/CT imaging is safe and may be valuable in discriminating incidental findings identified on 18F-FDG PET/CT from true positive lesions and in localizing metastatic LNs.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
完美世界应助稳重夜绿采纳,获得10
7秒前
Sunny完成签到,获得积分10
11秒前
15秒前
fanboyz完成签到 ,获得积分10
16秒前
yindi1991完成签到 ,获得积分10
17秒前
稳重夜绿发布了新的文献求助10
21秒前
暴躁的凌柏完成签到 ,获得积分10
33秒前
依然灬聆听完成签到,获得积分10
39秒前
呱呱乐完成签到,获得积分20
50秒前
共享精神应助科研通管家采纳,获得10
51秒前
耕牛热完成签到,获得积分10
1分钟前
1分钟前
和风完成签到 ,获得积分10
1分钟前
1分钟前
hanj发布了新的文献求助10
1分钟前
大个应助hanj采纳,获得10
1分钟前
Alicia完成签到 ,获得积分10
1分钟前
科研通AI2S应助tdtk采纳,获得10
2分钟前
嗯嗯嗯哦哦哦完成签到 ,获得积分10
2分钟前
科研通AI2S应助tdtk采纳,获得10
2分钟前
Andy_Cheung应助tdtk采纳,获得10
2分钟前
3分钟前
初陽应助tdtk采纳,获得30
3分钟前
hanj发布了新的文献求助10
3分钟前
传奇3应助hanj采纳,获得10
3分钟前
ommphey完成签到 ,获得积分10
3分钟前
热心市民小红花应助tdtk采纳,获得10
3分钟前
Liufgui应助小鉴采纳,获得30
3分钟前
111完成签到 ,获得积分10
3分钟前
小西米完成签到 ,获得积分10
3分钟前
深情安青应助tdtk采纳,获得10
3分钟前
zj完成签到 ,获得积分10
3分钟前
tdtk完成签到,获得积分10
3分钟前
4分钟前
4分钟前
4分钟前
liuyamei发布了新的文献求助10
4分钟前
liuyamei完成签到,获得积分10
4分钟前
慕青应助勤劳的尔蓉采纳,获得10
4分钟前
4分钟前
高分求助中
【重要!!请各位用户详细阅读此贴】科研通的精品贴汇总(请勿应助) 10000
Plutonium Handbook 1000
Three plays : drama 1000
International Code of Nomenclature for algae, fungi, and plants (Madrid Code) (Regnum Vegetabile) 1000
Semantics for Latin: An Introduction 999
Robot-supported joining of reinforcement textiles with one-sided sewing heads 580
Apiaceae Himalayenses. 2 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4091960
求助须知:如何正确求助?哪些是违规求助? 3630693
关于积分的说明 11507654
捐赠科研通 3341874
什么是DOI,文献DOI怎么找? 1836948
邀请新用户注册赠送积分活动 904831
科研通“疑难数据库(出版商)”最低求助积分说明 822585