Antibacterial and pro-angiogenic SIS-based bio-patches with poly(tannic acid) and magnesium facilitating abdominal wall repair

• A composite bio-patch based on the decellularized matrix of small intestinal submucosa (SIS) was proposed by surface-coating poly(tannic acid) (PTA) and magnesium ions (Mg 2+ ). • The SIS/PTA/Mg bio-patch demonstrated the excellent bacterial resistance (∼98 % antibacterial efficiency) and remarkable repair efficacy (3.83-fold to the commercial mesh). • The SIS/PTA/Mg bio-patch prevented post-operative infections, facilitated angiogenesis, and accelerated tissue regeneration. Abdominal wall injury is a common and challenging clinical condition, typically caused by trauma, surgical intervention, or congenital abnormalities. Traditional treatments face significant limitations in preventing infections and promoting tissue integration, highlighting the urgent need for innovative repair materials. In this study, we demonstrated a composite bio-patch based on the decellularized extracellular matrix of small intestinal submucosa (SIS), surface-coated with poly(tannic acid) (PTA) and magnesium ions (Mg 2+ ), which impart strong antibacterial properties while enhancing angiogenesis and tissue regeneration (named as SIS/PTA/Mg). Through in vitro cell assays, antibacterial assays, and rat abdominal wall defect animal model, the SIS/PTA/Mg bio-patch exhibited the excellent bacterial resistance (∼98 % antibacterial efficiency), favorable biocompatibility, and remarkable repair efficacy (3.83-fold to the commercial mesh). Meanwhile, the SIS/PTA/Mg bio-patch effectively prevented post-operative infections, significantly facilitated angiogenesis, and accelerated tissue regeneration, indicating this SIS/PTA/Mg composite bio-patch as an innovative and clinically promising solution for the treatment of abdominal wall injuries.