This study was funded by Natural Science Foundation of Shanghai (25ZR1401179), the National Key Research and Development Program of China (2022YFB4702702), the Sci-Tech Innovation 2030-Major Project of Brain Science and Brain-inspired Intelligence Technology (2021ZD0200600), Beijing Municipal Public Welfare Development and Reform Pilot Project for Medical Research Institutes (JYY2023-8), and National Key Research and Development Program of China (2024YFC3044700).