帽状体
衣壳
支架蛋白
噬菌体
顶点(图论)
折叠(高阶函数)
生物物理学
脚手架
螺旋线圈
病毒蛋白
蝗虫科
生物
结晶学
化学
病毒学
病毒
细胞生物学
遗传学
计算机科学
图形
信号转导
大肠杆菌
理论计算机科学
数据库
基因
程序设计语言
作者
Alexis Huet,Bonnie Oh,Joshua A. Maurer,Robert L. Duda,James F. Conway
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2023-06-16
卷期号:9 (24)
被引量:3
标识
DOI:10.1126/sciadv.adg8868
摘要
Tailed bacteriophages and herpesviruses use a transient scaffold to assemble icosahedral capsids with hexameric capsomers on the faces and pentameric capsomers at all but one vertex where a 12-fold portal is thought to nucleate the assembly. How does the scaffold orchestrate this step? We have determined the portal vertex structure of the bacteriophage HK97 procapsid, where the scaffold is a domain of the major capsid protein. The scaffold forms rigid helix-turn-strand structures on the interior surfaces of all capsomers and is further stabilized around the portal, forming trimeric coiled-coil towers, two per surrounding capsomer. These 10 towers bind identically to 10 of 12 portal subunits, adopting a pseudo-12-fold organization that explains how the symmetry mismatch is managed at this early step.
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