Realization of differential release of minocycline hydrochloride from electrosprayed polymeric or biomacromolecular microparticles for the repair of traumatic brain injury

experiments further proved that MH@SF and MH@PLGA microparticles alleviate the neuroinflammation microenvironment and enhance motor, learning, and memory functions of mice after TBI. In summary, this work proposed a promising strategy to regulate the neuroimmune microenvironment through matching different pathophysiological stages of TBI, demonstrating potential for clinical translation to treat TBI.