Asprosin Aggravates Tubular Epithelial Cell Injury and Phenotypic Transformation via Mitochondrial Dynamics Disorder Mediated by Excessive Drp1 SUMOylation in Diabetic Nephropathy Mice

) or ASP antibody (AASP) intervention significantly alleviates the kidney injury and mitochondrial dynamics disorder induced by STZ/HFD. These findings identify ASP as a novel predictor of DKD and offer new therapeutic strategies for DKD prevention and treatment.