The whitening efficacy of a compound formula examined using an ultraviolet‐induced skin melanization model

Abstract Background In Eastern culture, a fair complexion is the standard of beauty, leading to appearance‐related distress among women with darker skin or facial pigmentation. Women seek whitening cosmetics to enhance their skin tone or correct their pigmentation, but their safety and effectiveness are paramount factors to consider. In this study, we evaluated the safety and whitening effects of a compound formula denoted as TEST comprising astaxanthin, nicotinamide, arbutin, and tranexamic acid. Methods Primary skin irritation and skin‐whitening efficacy were examined. Three qualified melanization areas were treated with TEST, 7% ascorbic acid, or a blank. Skin color, the individual type angle (ITA°), and the melanin index (MI) were compared among treatment areas. Results TEST did not induce a skin response and exhibited a significantly higher ITA° than the blank, while no significant difference was observed with that of 7% ascorbic acid. Furthermore, the MI of TEST was significantly reduced posttreatment. Conclusions TEST could be integrated into spot‐fading and skin‐whitening cosmeceuticals or functional cosmetics.